Hello! I’m Etowah, a second year PhD student in Systems Biology at Columbia studying machine learning and biology. I am advised by Prof. Mohammed AlQuraishi. In my research I seek to build increasingly complete (re: multi-modal, temporal, molecular) representations of biology to understand and engineer biology.

No, not a Pollock painting. It’s a DNA sequencing flow cell in action.

In my undergrad at Yale, I developed CRISPR-based gene editing tools with Prof. Farren Isaacs. Subsequently, I worked at Harvard Medical School as a research software engineer with Prof. Nils Gehlenborg on tools for genomics data. I also developed software at Ginkgo Bioworks as an intern. I’m originally from southern Applachia where I grew up on a small farm.

I am happy to chat about research or anything else! Feel free to reach out. A few things I love discussing: self-supervised learning, mechanistic interpretability, protein structure prediction, amortized sampling, cloud labs, optimal experimental design, expansion microscopy, CryoET, WebGL, and banjo.

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2025

From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models thumbnail
From Mechanistic Interpretability to Mechanistic Biology: Training, Evaluating, and Interpreting Sparse Autoencoders on Protein Language Models
Etowah Adams*, Liam Bai*, Minji Lee, Yiyang Yu, Mohammed AlQuraishi
International Conference on Machine Learning (ICML), 2025 (Spotlight)
First paper of my PhD! Using sparse autoencoders, we try to figure out what protein langauge models have learned about proteins.
Genome modeling and design across all domains of life with Evo 2 thumbnail
Genome modeling and design across all domains of life with Evo 2
Garyk Brixi*, Matthew G. Durrant*, Jerome Ku*, Michael Poli*, Greg Brockman, ..., Etowah Adams, ..., Dave P. Burke, Hani Goodarzi, Patrick D. Hsu, Brian L. Hie
Preprint
I led engineering of Evo Designer. Huge thanks to Arc Insitute and Patrick Collison for the opportunity to contribute!
Precision multiplexed base editing in human cells using Cas12a-derived base editors thumbnail
Precision multiplexed base editing in human cells using Cas12a-derived base editors
Anabel Schweitzer, Etowah Adams, Michael Nguyen, Monkol Lek, Farren J. Isaacs
Nature Communications
Paper from my undergrad. I developed analysis tools for base editing outcome sequencing data.

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